acylation stimulation protein

Hoppas ni har läst tidigare inlägg om vår kost där vi diskuterat sambanden mellan Insulin - fettlagring och Glykagon - fettförbränning.

En fråga man kan ställa sig är hur kroppen om den är inställt på fettförbränning dvs det som sker när vi äter en kost i huvudsak baserad på fett och protein undviker att helt köra slut på alla fettdepåer i kroppen?

Vi måste ju som bekant alltid ha en viss fettnivå i kroppen. Nu visar senaste forskning att kroppen i ett mycket intrikat och komplext system visst kan lagra fett även när vi undviker kolhydrater och detta bla mha ett hormon kallat acylation stimulation protein, eller förkortat ASP.

Samtidigt finns andra mekanismer som när vi äter fett reglerar vår mättnadskänsla så att kroppen när systemet fungerar säger ifrån i tid och vi omöjligen klarar att äta mer fett än det som kroppen behöver.

Vill du läsa mer läs nedanstående länk i sin helhet:

"ASP is another hormone secreted by fat cells, with several effects. First, ASP can increase LPL activity, making fatty acids available for transport into the fat cells. Second, ASP increases the expression of glucose transporters in fat cells, allowing them to bring in the glucose required to store fat. So ASP plays roughly the same role as insulin in fat storage, but rather than being generated by the pancreas in response to carbohydrates, is generated by the fat cells themselves. Better yet, ASP stimulates the production of triglycerides inside the fat cells.

But what causes ASP to be secreted? The answer, at least in test-tubes, is chylomicrons. When fat cells are exposed to chylomicrons they generate lots of ASP. By contrast, exposing the same cells to glucose, fatty acids, VLDL, HDL, or LDL elicits little ASP response. Further, the ASP response exhibits both a time and concentration dependence on chylomicron concentration."

"Eat lots of fat, intestines create lots of chylomicrons. Chylomicrons stimulate fat cells to make ASP, which in turn increases fat storage. As fat cells store fat, they release leptin, which suppresses appetite and sensitizes the body to other satiety signals. But chylomicrons are fairly quickly turned into VLDL, which do not stimulate fat storage, but do make fat available for energy. The brain can detect VLDL levels, and regulate gastric emptying, appetite, etc. until the fat in the VLDL is used up. And that's just one of a complex web of interactions between hormones, the nervous system, metabolism, and digestion."

A swift kick in the ASP
http://sparkofreason.blogspot.com/2008/06/swift-kick-in-asp.html

Kunskap är makt
http://intheendwerealldebt.blogspot.com/2008/11/kunskap-r-makt.html

Det farliga insulinet
http://intheendwerealldebt.blogspot.com/2008/12/det-farliga-insulinet.html

Good Calories, Bad Calories - Gary Taubes
Starred Review. Taubes's eye-opening challenge to widely accepted ideas on nutrition and weight loss is as provocative as was his 2001 NewYork Times Magazine article, What if It's All a Big Fat Lie? Taubes (Bad Science), a writer for Science magazine, begins by showing how public health data has been misinterpreted to mark dietary fat and cholesterol as the primary causes of coronary heart disease. Deeper examination, he says, shows that heart disease and other diseases of civilization appear to result from increased consumption of refined carbohydrates: sugar, white flour and white rice. When researcher John Yudkin announced these results in the 1950s, however, he was drowned out by the conventional wisdom. Taubes cites clinical evidence showing that elevated triglyceride levels, rather than high total cholesterol, are associated with increased risk of heart disease-but measuring triglycerides is more difficult than measuring cholesterol. Taubes says that the current U.S. obesity epidemic actually consists of a very small increase in the average body mass index. Taube's arguments are lucid and well supported by lengthy notes and bibliography. His call for dietary advice that is based on rigorous science, not century-old preconceptions about the penalties of gluttony and sloth is bound to be echoed loudly by many readers
http://www.amazon.com/gp/product/1400040787?ie=UTF8&tag=thespaofrea-20&link_code=wql&camp=212361&creative=380601

What if It's All Been a Big Fat Lie?
http://query.nytimes.com/gst/fullpage.html?res=9F04E2D61F3EF934A35754C0A9649C8B63